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They help regulate growth and the rate of chemical reactions (metabolism), and are involved in the circadian rhythms that govern sleep, among other essential functions. For example, prodrugs can be slowly converted to the compounds of the present invention when placed in a transdermal patch reservoir with a suitable enzyme or chemical reagent.	Natural products are an unsurpassed source of evolved chemical diversity and therefore represent a rich starting point for screening programs aimed at generating pharmacologically active small molecule leads.
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